The Biozentrum of Basel University is the largest department at the University of Basel’s Faculty of Science. The primary focus of this interdisciplinary institute is basic molecular and biomedical research and teaching. The Biozentrum holds a leading position nationally and internationally and closely networks with partners from the academic world and industry. The Center for Cellular Imaging and NanoAnalytics (C-CINA) advances and applies analytical methods for the characterization of cellular and sub-cellular structures. The main focal points of our biological research are understanding the structure and function of membrane proteins and the aggregation mechanisms involved in neurodegeneration, particularly Alzheimer’s and Parkinson’s disease, of mitochondrial responses to stress and the connections between these two processes. A major focal point at C-CINA / group Abrahams in methods development concerns electron diffraction as tool for structure determination of crystalline and non-crystalline organic samples.
Key Research Facilities
Electron microscopes at C-CINA / BioEM lab are a Titan Krios, a Glacios, Talos, and a Polara; the latter two equipped with hybrid pixel electron diffraction detectors; a second Titan Krios will be purchased on 2020, installed in 2021. Dedicated electron diffraction instruments at C-CINA / BioEM lab: 200 keV FEG EM, CEOS energy filter, Nanomegas DIGISTAR scanning device, PSI Jungfrau direct electron detector (2kx2k pixels); to be established in 2020.
Electron microscopes at the PSI: a Jeol JEM2200FS with Nanomegas’ DIGISTAR beam scanning device and GaAs Medipix3 electron diffraction detector
Computational facilities at sciCORE (Basel University) and PSI.